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The Research Making Health for All Possible

The scientists behind the Dr. Rath Research Institute, led by Dr. Aleksandra Niedzwiecki, fifth
from left.

The two-time Nobel Laureate Linus Pauling stated that Dr. Rath's discoveries will be seen as among the most important of the 20th century. For more than a decade, Dr. Rath and a focused expert team of researchers led by Dr. Aleksandra Niedzwiecki have built on, supported and expanded Dr. Rath's discoveries. Today, the wealth of research that they have documented and published is both prodigious and compelling. Approximately 70 research studies by Dr. Rath and other members of the Institute have appeared in peer-reviewed scientific journals and book chapters, or been presented at scientific meetings around the world.

Click on either of the names below to view some of their research.

Matthias Rath, M.D.
Aleksandra Niedzwiecki, Ph.D.

Selected research publications by Matthias Rath, M.D.

Leading Publications which lay down the foundation for Cellular Medicine

Lipoprotein(a) Is a Surrogate for Ascorbate (1990)
M. Rath
Proceedings of the National Academy of Sciences, 87: 6204-6207.
The concept that lipoprotein(a) is a surrogate for ascorbate is suggested by the fact that this lipoprotein is found generally in the blood of primates and the guinea pig, which have lost the ability to synthesize ascorbate; but only rarely in other animals. Properties shared with ascorbate, in accordance with this hypothesis, are the acceleration of wound healing and of cell repair mechanisms, strengthening of the extracellular matrix (as in blood vessels), and prevention of lipid peroxidation. Evidence supporting this hypothesis is discussed.
Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause Is Ascorbate Deficiency, Leading to the Deposition of Lipoprotein(a) and Fibrinogen/Fibrin in the Vascular Wall (1991)
M. Rath, L. Pauling
Journal of Orthomolecular Medicine, 6: 125-134.
This article proposes that human cardiovascular disease is primarily a nutrient deficiency of vitamin C, leading to the accumulation of lipoprotein(a), and other blood factors in the vascular wall as a means to stabilize the vascular wall structure. Ascorbate deficiency is the consequence of the inability of humans to synthesize endogenous ascorbate combined with an insufficient dietary ascorbate intake. Chronic ascorbate deficiency leads to extracellular accumulation of lipoprotein(a) [LDL] and fibrinogen/fibrin, the hallmarks of the atherosclerotic lesion.
Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality (1992)
M. Rath, L. Pauling
Journal of Orthomolecular Medicine, 7: 5-15.
In contrast to current therapeutic approaches, which target individual pathomechanisms or specific risk factors for CVD, this paper proposes a unified pathogenetic and therapeutic approach based on genetic, metabolic, evolutionary and clinical evidence - ascorbate deficiency. Chronic ascorbate deficiency leads to the impairment of the connective tissue in the vascular wall and compensatory deposition of Lp(a) (lipoprotein(a)) and fibrinogen/fibrin.
Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs (1992)
M. Rath, L. Pauling
Journal of Orthomolecular Medicine, 7: 17-23.
Proteolytic degradation of extracellular matrix (ECM) by the protease plasmin is a universal mechanism, determining human health and disease. Under physiological conditions, it allows cell migration and organ remodeling. Under pathological conditions, however, it allows sustained degradation of the ECM, as associated with cancer, viral spread, and cardiovascular disease. In this paper, lysine and synthetic lysine analogs are discussed as inhibitors of plasmin-induced proteolysis and proposed as natural therapeutic options to control pathological conditions associated with excessive extracellular matrix degradation.
Solution to the Puzzle of Human Evolution (1992)
M. Rath
Journal of Orthomolecular Medicine, 7: 73-80.
This article discusses the rationale for the proposal that the underlying genetic precondition for the evolution of man was the loss of endogenous ascorbate production about 40 million years ago. This genetic mutation became the basis of the dramatic acceleration of human evolution and a quadruplication of the brain size in the recent 2.5 million years. Scurvy, the greatest threat to evolutionary survival of ascorbate-deficient man during the Ice Age, led to survival genetic features: Lipoprotein(a) for stabilizing the vascular wall and apoprotein(a) for increased brain size, intelligence and fertility.
A New Era in Medicine (1993)
M. Rath
Journal of Orthomolecular Medicine, 8: 134-135.
This article proposes that, in contrast to the past, the 21st century will see the eradication of major diseases, such as CVD, and the establishment of nutritional medicine as an essential part of the healthcare system. Skepticism and bias against nutritional supplements will be replaced by acceptance of vitamins and essential nutrients as safe and affordable preventative and therapeutic agents, based on an objective scientific attitude towards nutrient medical research.

Experimental Research:

Heart Disease Bioflavonoids Effectively Inhibit Smooth Muscle Cell-Mediated Contraction of Collagen Matrix Induced by Angiogtensin-II
V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
The Journal of Cardiovascular Pharmacology (2005), 46(5): 570-6
Reduction In The Frequency Of Arrhythmic Epidsodes In Patients With Paroxysmal Atrial Arrhythmia With A Vitamin/Essential Nutrient Program
M. Rath T. Kalinovsky, A. Niedzwiecki,
JANA (2005), 8(3): 21-25.
Extracellular Matrix-Mediated Control of Smooth Muscle Cell Growth and Migration by a Combination of Ascorbic Acid, Lysine, Proline and Catechins
V. Ivanov, S. Ivanova, M.W. Roomi, A. Niedzwiecki, M. Rath
Matthias Rath BV - Santa Clara, CA
Atherosclerosis (2005), vol. 6, issue 1, p.18.
Enhancement of Cardio-Protective Effects and Attenuation of Adverse Effects of Female Sex Hormones on Cultured Human Vascular Smooth Muscle Cells by a Combination of Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Epigallocatechin Gallate
V. Ivanov, S. Ivanova, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
JANA (Jan.2005), 7(3): 17-22.
A Nutrient Mixture Containing Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Green Tea Extract Suppresses Autocrine Inflammatory Response in Cultured Human Aortic Smooth Muscle Cells
V. Ivanov, S. Ivanova, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
Research Communications in Pharmacology Toxicology (2004), 9: 3-16.
Nutritional Supplement Program Halts Progression of Early Coronary Atherosclerosis Documented by Ultrafast Computed Tomography
M. Rath, A. Niedzwiecki
Journal of Applied Nutrition (1996), 48: 68-78.
Lipoprotein(a) Reduction by Ascorbate
M. Rath
Journal of Orthomolecular Medicine (1992), 7: 81-82.
Anti-Atherosclerotic Effect of Probucol in WHHL Rabbits: Are There Plasma Parameters to Evaluate this Effect?
B. Finckh, A. Niendorf, M. Rath, U. Beisiegel
European Journal of Clinical Pharmacology (1991), 40: 77-80.
Immunological Evidence for the Accumulation of Lipoprotein(a) in the Atherosclerotic Lesion of the Hypoascorbemic Guinea Pig
M. Rath, L. Pauling
Proceedings of the National Academy of Sciences USA (1990), 87: 9388-9390.
Lipoprotein(a) in the Arterial Wall
U. Beisiegel, A. Niendorf, K. Wolf, T. Reblin, M. Rath
European Heart Journal 11 (1990), (Supp. E): 174-83.
Morphological Detection and Quantification of Lipoprotein(a) Deposition in Atheromatous Lesions of Human Aorta and Coronary Arteries
A. Niendorf, M. Rath, K. Wolf, S. Peters, H. Arps, U. Beisiegel, M. Dietel Virchow's Archive of Pathological Anatomy (1990), 417: 105-111.
Detection and Quantification of Lipoprotein(a) in the Arterial Wall of 107 Coronary Bypass Patients
M. Rath, A. Niendorf, T. Reblin, M. Dietel, HJ Krebber, U. Beisiegel Arteriosclerosis (1989), 9: 579-592.

Cancer

Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Novel Nutrient mixture
M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath
Experimental Lung Research (2006), 32: 69-79.
Suppression of Human Cervical Cancer Cell Lines Hela and DoTc2 4510 MMP Expression and Matrigel Invasion by a mixture of lysine, proline, ascorbic acid, and green tea extract
M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath
Int. J Gynecol Cancer (2006), 16: 1241-1247.
Anti-tumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Bladder Cancer Cell Line T-24
M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Urology (2006), 13: 413-417.
Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity by Inhibitors and Inducers in Vitro
M.W. Roomi, N. Roomi, V. Ivanov,T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology (2006), 23(2): 245-250.
Inhibition of MMP-2 Secretion and Invasion by Human Ovarian Cancer Cell Line SK-OV-3 with Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal of Obstetrics and Gynecology Research (2006), 32,141-147.
In Vivo and In Vitro Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Human Fibrosarcoma Cells HT-1080
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology (2006), 23(1): 105-112.
In Vitro and In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, And Green Tea Extract On Human Melanoma Cell Line A2058
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
In Vivo (2006), 20(1): 25-32.
Apoptosis Induction by Nutrient Synergy in HTLV-1 Positive and Negative Malignant T-Cells
S. Harakeh, M. Diab-Assaf, A. Niedzwiecki, J. Khalife, K. Abu-El-Ardat, M. Rath
Leukemia Research 30 (2006), p.869-881.
Inhibitory Effect Of A Mixture Containing Ascorbic Acid, Lysine, Proline, And Green Tea Extract On Critical Parameters In Angiogenesis
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Oncology Reports (2005), 14(4): 807-815.
In Vitro and In Vivo Antitumorigenic Activity of a Mixture of Lysine, Proline, Ascorbic Acid and Green Tea Extract on Human Breast Cancer Lines MDA MB-231 and MCF-7
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology (2005), 22(2): 129-38.
Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid, and Green Tea Extract on Pancreatic Cancer Cell Line MIA PaCa-2
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Gastrointestinal Cancer (2005), 35(2): 97-102.
Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cells U2OS, MNNG-HOS, and Ewing’s Sarcoma SK-ES.1
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Oncology Reports (2005), 13(2): 253-257.
Modulation of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in Sprague-Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract
M.W. Roomi, V. Ivanov ,T. Kalinovsky, A. Niedzwiecki, M. Rath
Breast Cancer Research (2005), 7: R291-R295.
In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Prostate Cancer PC-3 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
In Vivo (2005), 19(1): 179-184.
In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Oncology Reports (2005), 12(3): 421-425.
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Epigallocatechin Gallate in Prostate Cancer Cell Lines PC-3, LNCaP, and DU145
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Research Communications in Molecular Pathology and Pharmacology (2004), 115, 1-6.
Synergistic Effect of Combination of Lysine, Proline, Arginine, Ascorbic Acid and Epigallocatechin Gallate on Colon Cancer Cell Line HCT 116
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal of the American Nutraceutical Association (2004), 7(2): 40-43.
In Vivo and In Vitro Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cell Line MNNG-HOS
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy (2004), 12(1&2): 135-145.
Synergistic Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Epigallocatechin Gallate on Human Fibrosarcoma Cells HT-1080
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy (2004), 12(1&2): 146-156.
A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Cancer Cell Lines
S. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Research Communications in Pharmacology and Toxicology Emerging Drugs (2003), 2: 37-5.
Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs
M. Rath, L. Pauling
Journal of Orthomolecular Medicine (1992), 7: 17-23.

Other Research

Natural Nutrient Mixture Effectively Reduces Collagen Matrix Contraction Driven by Human Uterine Smooth Muscle Cells
V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M.Rath
Journal of Obstetrics and Gynecology Research (2006), 32(1): 23-31.

Anti-Angiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothelial Cells
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Oncology Reports (2005), 14: 1399-1404.
Reduction in Tibial Shaft Fracture Healing Time With Essential Nutrient Supplementation Containing Ascorbic Acid, Lysine, and Proline
Jamdar J, Rao B, Netke S, Roomi MW, Ivanov V, Niedzwiecki A, Rath M.
“Letter to the Editor” - Journal of Alternative and Complementary Medicine (2004), 10(6), 915-916.
Antioxidant Supplements and Simvastatin-Niacin Therapy
S. Netke, V. Ivanov, M.W. Roomi, A. Niedzwiecki, M. Rath
“Letter to the Editor” - Arteriosclerosis, Thrombosis and Vascular Biology (2001), Vol. 21, No.12, p.2099-2100.

Books Published

Eradicating Heart Disease
Why Animals Don't Get Heart Attacks But People Do
Good Health - Do It Yourself!
Cellular Health Series: The Heart
Cellular Health Series: Cancer
Cellular Health Series: Ten Years That Changed Medicine Forever
Cellular Health Series: Health for the 21st Century
The Cellular Health Solution to Irregular Heartbeat: Results of a Randomized, Double-Blind Placebo-Controlled Clinical Study

Selected research publications by Aleksandra Niedzwiecki, Ph.D.

Selected Publications

Heart Disease

Reduction in the Frequency of Arrhythmic Epidsodes in Patients with Paroxysmal Atrial Arrhythmia with a Vitamin/Essential Nutrient Program (2005)
M. Rath, T. Kalinovsky, A. Niedzwiecki
JANA, 8, 21-25.
Bioflavonoids Effectively Inhibit Smooth Muscle Cell-Mediated Contraction of Collagen Matrix Induced by Angiotensin-II (2005)
V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
The Journal of Cardiovascular Pharmacology, 46, 570-600.
Extracellular Matrix-Mediated Control of Smooth Muscle Cell Growth and Migration by a Combination of Ascorbic Acid, Lysine Proline and Catechins (2005)
V. Ivanov, S. Ivanova, M.W. Roomi, A. Niedzwiecki, M. Rath
Atherosclerosis, 6, 18.
Enhancement of Cardio-Protective Effects and Attenuation of Adverse Effects of Female Sex Hormones on Cultured Human Vascular Smooth Muscle Cells by a Combination of Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Epigallocatechin Gallate (2005)
V. Ivanov, S. Ivanova, M.W. Roomi, T. Kalinovski, A. Niedzwiecki, M. Rath
JANA,.7, 17-22.
A Nutrient Mixture Containing Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Green Tea Extract Suppresses Autocrine Inflammatory Response in Cultured Human Aortic Smooth Muscle Cells (2004)
V. Ivanov, S. Ivanova, M.W. Roomi, T. Kalinovski, A. Niedzwiecki, M. Rath
Research Communications in Pharmacology and Toxicology, 9, 3-16.
Letter to Editor: Antioxidant Supplements and Simvastatin-Niacin Therapy (2001)
S.P. Netke, V. Ivanov, M.W. Roomi, A. Niedzwiecki, M. Rath
Arterioscler Thromb Vasc. Biol., 21, 2099-2100.
Transforming Growth Factor-Beta 1 and Ascorbate Regulate Proliferation of Cultured Smooth Muscle Cells by Independent Mechanisms (1998)
V. Ivanov, A.B. Rabovsky, S. Ivanova, A. Niedzwiecki
Atherosclerosis,.140, 25-34.
Progression of Early Stages of Coronary Calcifications Can Be Stopped by the Synergistic Effect of Vitamins and Essential Nutrients (1997)
M. Rath, A. Niedzwiecki
Atherosclerosis, 134, 333.
Ascorbate Affects Proliferation of Guinea Pigs Vascular Smooth Muscle Cells by Direct and Extracellular Matrix Mediated Effects (1997)
V. Ivanov, S. Ivanova, A. Niedzwiecki
J.Mol.Cell.Cardiol., 29, 3293-3303.
Nutritional Supplement Program Halts Progression of Early Coronary Atherosclerosis Documented by Ultrafast Computed Tomography (1996)
M. Rath, A. Niedzwiecki
J.Appl. Nutr., 48, 67-78.
Liver Antioxidants in Guinea Pigs Fed Atherogenic Diet with Varying Intake of Ascorbic Acid (1995)
S. P. Netke, A. Niedzwiecki
Int. J.Vit. Res., 65, 187-192.

Cancer

Apoptosis Induction by Epican Forte in HTLV-1 Positive and Negative Malignant T-Cells (2006)
S. Harakeh, M. Diab-Assaf, A. Niedzwiecki, J. Khalife, Abu-El-Ardat, M. Rath
Leukemia Research, 30, 869-881.
Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Nobel Nutrient Mixture (2006)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Experimental Lung Research, 32,69-79.
Effect of Ascorbic Acid, Lysine, Proline and Green Tea Extract Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry (2006)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology, In Print
Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity by Inhibitors and Inducers in Vitro (2006)
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology, 23, 245-250
In Vitro and In Vivo Antitumor Effect of Ascorbic Acid. Lysine, Proline and Green Tea Extract on Human Melanoma Cell Line A2058 (2006)
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
In Vivo, Vol. 20, Issue 1, pp.25-32.
Inhibition of MMP-2 Secretion and Invasion by Human Ovarian Cancer Cell Line SK-OV-3 with Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract (2006)
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal of Obstetrics and Gynecology Research, 32,141-147.
Suppression of Human Cervical Cancer Cell Lines Hela and DoTc2 4510 MMP Expression and Matrigel Invasion by a Mixture of Lysine, Proline, Ascorbic Acid and Green Tea Extract (2006)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath International Journal of Gynecological Cancer, 16, 1241-1247.
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Green Tea Extract on Bladder Cancer Cell Line T-24 (2006)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Urology, 13, 415-419.
In Vivo and In Vitro Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Green Tea Extract on Human Fibrosarcoma Cells HT-1080 (2006)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology, 23, 105-112.
Antitumor Effect of a Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea on Pancreatic Cancer Cell Line MIA PaCa-2 (2005)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Gastrointestinal Cancer, 35, 97-102.
Inhibitory Effect of a Mixture Containing Ascorbic Acid, Lysine, Proline and Green Tea Extract on Critical Parameters in Angiogenesis (2005)
M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Oncology Reports, 14, 807-815.
In Vitro and In Vivo Antitumorigenic Activity of a Mixture of Lysine, Proline, Ascorbic Acid and Green Tea Extract on Human Breast Cancer Lines MDA-MB-231 and MCF-7 (2005)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Medical Oncology, 22, 129-138.
Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cells U2OS, MNNG-HOS, and Ewing’s Sarcoma SK-ES.1 (2005)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Oncology Reports, 13, 253-257.
Modulation of N-Methyl –N-Nitrosourea-Induced Mammary Tumors in Sprague-Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract (2005)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath,
Breast Cancer Research, 7, R291-R295.
In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Prostate Cancer PC-3 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry (2005)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
In Vivo, 19, 179-184.
In Vivo Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Colon Cancer Cell HCT 116 Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry (2005)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Oncology Reports, 12, 421-425.
Synergistic Antitumor Effect of Ascorbic Acid, Lysine, Proline, and Epigallocatechin Gallate on Human Fibrosarcoma Cells HT-1080 (2004)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy, 12, 146-156.
In Vivo and In Vitro Antitumor Effect of Nutrient Synergy on Human Osteosarcoma Cell Line MNNG-HOS1 (2004)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Annals of Cancer Research and Therapy, 12, 137-148.
Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Epigallocatechin Gallate in Prostate Cancer Cell Lines PC-3, LNCaP and DU145 (2004)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Research Communications in Molecular Pathology and Pharmacology, 115, 1-6.
Synergistic Effect of Combination of Lysine, Proline, Arginine, Ascorbic Acid and Epigallocatechin Gallate on Colon Cancer Cell Line HCT 116 (2004)
M.W. Roomi, V. Ivanov, T. Kalinovski, A. Niedzwiecki, M. Rath
Journal of the American Nutraceutical Association, 7, 40-43.
Inhibition of Tumor Growth of Human Breast, Prostate, Colon and Melanoma Cancers Xenographs by Nutrient Synergy in Nude Mice (2003)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Mol.Cell.Biol., 14, Suppl. 921.
A Specific Combination of Ascorbic Acid, Lysine, Proline and Epigallocatechin Gallate Inhibits Proliferation and Extracellular Matrix Invasion of Various Human Cancer Cell Lines (2003)
S.P. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Research Communications in Pharmacology and Toxicology, Emerging Drugs, Vol. II, IV37-IV50.
Nutrients Counteract Cancerogenic Activity of Estrogen in Cultured Human Cancer Cells (2003)
M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
J.Am.Coll.Nutr., 23, 18.
Inhibitory Effect of Epican Forte- A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate on Matrix Metalloproteinases Activities and Invasion of Human Fibrosarcoma HT-1080 Cells (2003)
M.W. Roomi, V. Ivanov, S.P. Netke, M. Rath, A. Niedzwiecki
FASEB Journal, 8452
A novel In Vitro Bioassay for Screening Matrix Metalloproteinases Activity in Human Cancer Cell Lines (2003)
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath, A. Niedzwiecki
Proc. Am. Assoc. Cancer. Res., 44, 4559.
Metastatic and Cytotoxic Effects of Ascorbigen and Iso-Ascorbigen in Human Cancer Cell Lines (2002)
M.W. Roomi, A. Bogale, V. Ivanov, S.P. Netke, A. Niedzwiecki, M. Rath
J. Am. Coll. Nut., 21, 54.
Cytotoxic effect of Lipophilic Substitution at 2-, 6- and 2,6- Positions in Ascorbic Acid and Expression of Matrix Metalloproteinases in HepG2 Cells, Melanoma Cells and Normal Human Dermal Fibroblasts (2001)
M. W. Roomi, S.P. Netke, V. Ivanov, A. Niedzwiecki, M. Rath, J.Am.Coll.Nutr., 20, 57

Various research aspects:

Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells (2008)
Harakeh S, Abu-El-Ardat K, Diab-Assaf M, Niedzwiecki A, El-Sabban M, Rath M
Medical Oncology, 25 (1), 30-9.
Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids (2007)
Jariwalla R, Roomi MW, Gangapurkar B, Kalinovsky T, Niedzwiecki A, Rath M
Biofactors, 31 (1),1-15.
Natural Nutrient Mixture Effectively Reduces Collagen Matrix Contraction Driven by Human Uterine Smooth Muscle Cells (2006)
V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
Journal of Obstetrics and Gynecology Research, Vol.32, 23-31.
Antiangiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothelial Cells (2005)
M.W. Roomi, N.Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Oncology Reports, 14, 1339-1404.
Reduction in Tibial Shaft Fracture Healing Time with Essential Nutrient Supplementation Containing Ascorbic Acid, Lysine and Proline (2004)
J. Jamdar, B.Rao, S.P. Netke, M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Journal of Alternative and Complementary Medicine, 10, 915-916.
Ascorbic Acid Protects Against Acute Aflatoxin Toxicity in Guinea Pig (1995)
S. P. Netke, A. Niedzwiecki, M. W. Roomi, C. S. Tsao
FASEB J, 825.
Ascorbic Acid Protects Guinea Pigs from Acute Aflatoxin Toxicity
S. P. Netke, M. W. Roomi, C.S. Tsao, A. Niedzwiecki
J. Toxicol (1996), 143, 429-435.
Ascorbic Acid Protects Against Acute Aflatoxin Toxicity in Guinea Pig (1995)
S. P. Netke, A. Niedzwiecki, M. W. Roomi, C. S. Tsao
FASEB J, 825.
Spotlighting the Biological Antioxidants (1994)
A. Niedzwiecki
LPI Newsletter, Spring/Summer, p.1-3.
Mechanistic Aspects of Ascorbate Inhibition of Human Immunodeficiency Virus (1994)
S. Harakeh, A. Niedzwiecki, R. Jariwalla
Chemico-Biol. Interactions, 91, 207-215.
Free Radicals and Antioxidants. What Are Their Roles in Our Health? (1994)
A. Niedzwiecki, C.S. Tsao
LPI Newsletter, Autumn/Winter, pp.1-2.
Stress Induced Expression of Cu/Zn Superoxide Dismutase and Catalase in Senescent Drosophila Melanogaster in New Strategies in Prevention and Therapy, Biological Oxidants and Antioxidants (1994)
J.E. Fleming, A. Niedzwiecki, I. Reveillaud
K. Schmidt (ed.)
Hippokrates Verlag, Stuttgart, pp.181-192.
Heat Shock Induces Changes in The Expression and Binding of Ubiquitin in Senescent Drosophila Melanogaster (1993)
A. Niedzwiecki, J.E. Fleming
Dev. Genet., 14, 78-86.
Effect of Oxidative Stress and Antioxidants on Heat Shock Response in Aging Drosophila (1992)
A. Niedzwiecki, J.E. Fleming
Age (Chester) 15, 138.
>Role of Oxidative Stress in Drosophila Aging (1992)
J.E. Fleming, I. Reveillaud, A. Niedzwiecki
Mutat. Res.,.275, 267-279.
Changes in Superoxide Dismutase and Catalase in Aging Heat-shocked Drosophila (1992)
A. Niedzwiecki, I. Reveillaud, J.E. Fleming
Free Rad. Res. Commun. 17, 355-367.
Aging Affects The Expression of Drosophila Heat Shock Proteins in New Horizons in Aging Research (1992), H. Orimo, Y. Fukuchi, K. Kuramoto, M. Iriki (eds)
A. Niedzwiecki
Univ. of Tokyo Press, pp.53-54.
Expression of Bovine Superoxide Dismutase in Drosophila Augments Resistance to Oxidative Stress (1991)
I. Reveillaud, A. Niedzwiecki, K.G. Bensch, J.E. Fleming.
Mol.Cell.Biol. 11, 1026-1030.
Aging Affects Expression of Hsp70 in Drosophila (1991)
A. Niedzwiecki, A. Kongpachith, J.E. Fleming
J.Biol.Chem. 266, 9332-9338.
Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster (1990)
A. Niedzwiecki, J.E. Fleming
Mech.Aging Dev, 52, 295-304